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Goldfrank's Toxicology
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Instructor Edition
Goldfrank's Toxicologic Emergencies, 8/e

Neal E. Flomenbaum
Lewis R. Goldfrank
Robert S. Hoffman
Mary Ann Howland
Neal A. Lewin
Lewis S. Nelson

ISBN: 0071437630
Copyright year: 2006

Table of Contents



Table of Contents

1. Historical Principles and Perspectives
Paul M. Wax

A1 Antiquated Antidotes in Depth
Paul M. Wax

2. Toxicologic Plagues and Disasters in History
Paul M. Wax


Part A. The General Approach to Medical Toxicology

3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes
Neal E. Flomenbaum, Lewis R. Goldfrank, Robert S. Hoffman,
Mary Ann Howland, Neal A. Lewin and Lewis S. Nelson

4. Principles of Managing the Poisoned or Overdosed Patient
Neal E. Flomenbaum, Lewis R. Goldfrank, Robert S. Hoffman
Mary Ann Howland, Neal A. Lewin and Lewis S. Nelson

5. Electrocardiographic Principles
Cathleen Clancy

6. Diagnostic Imaging
David T. Schwartz

7. Laboratory Principles
Petrie M. Rainey

8. Techniques Used to Prevent Gastrointestinal Absorption
Bolette Christophersen and Lotte C. G. Hoegberg

A2 Syrup of Ipecac
Mary Ann Howland

A3 Activated Charcoal
Mary Ann Howland

A4Whole Bowel Irrigation and Other Intestinal Evacuants
Mary Ann Howland

9. Pharmacokinetic and Toxicokinetic Principles
Mary Ann Howland

10. Principles and Techniques Applied to Enhance Elimination
David S. Goldfarb and Daniel Matalon

11. Intensive Care
Mark A. Kirk and J. Samuel Pope


Part B. The Fundamental Principles of Medical Toxicology

Section I. Biochemical and Molecular Basis

12. Chemical Principles
Stephen J. Traub and Lewis S. Nelson

13. Biochemical and Metabolic Principles
Kurt C. Kleinschmidt and Kathleen A. Delaney

14. Neurotransmitters and Neuromodulators
Steven C. Curry, Kirk C. Mills and Anne-Michelle Ruha

15. Withdrawal Principles
Richard J. Hamilton

Section II. Pathophysiological Basis: Organ Systems

16. Thermoregulatory Principles
Susi U. Vassallo and Kathleen A. Delaney

17. Fluid, Electrolyte, and Acid-Base Principles
Alan N. Charney and Robert S. Hoffman

18. Psychiatric Principles
Mark R. Serper and Michael H. Allen

19. Neurologic Principles
Rama B. Rao

20. Ophthalmic Principles
Adhi Sharma, Martin J. Smilkstein, and Frederick W. Fraunfelder,

21. Otolaryngologic Principles
William K. Chiang

22. Respiratory Principles
Robert S. Hoffman

23. Cardiovascular Principles
Robert A. Hessler

24. Hematologic Principles
Marco L. A. Sivilotti

25. Gastrointestinal Principles
Donald Kotler and Neal E. Flomenbaum

26. Hepatic Principles
Kathleen A. Delaney

27. Renal Principles
Donald A. Feinfeld and Vincent L. Anthony

28. Genitourinary Principles
Jason Chu

29. Dermatologic Principles
Dina Began

Section III. Special Populations

30. Reproductive and Perinatal Principles
Jeffrey S. Fine

31. Pediatric Principles
Jeffrey S. Fine

32. Geriatric Principles
Judith C. Ahronheim and Mary Ann Howland

33. Postmortem Principles
Rama B. Rao and Mark Flomenbaum

SC-1 Special Considerations: Organ Procurement from Poisoned Patients
Rama B. Rao


Part C. The Clinical Basis of Medical Toxicology

Section I. Case Studies

34. Acetaminophen
Rob G. Hendrickson and Kenneth E. Bizovi

A5 N-Acetylcysteine
Mary Ann Howland

35. Salicylates
Neal E. Flomenbaum

A6Sodium Bicarbonate
Paul M. Wax

36. Nonsteroidal Antiinflammatory Drugs
Martin G. Belson and William A. Watson

37. Colchicine and Podophyllin
Joshua G. Schier

38. Opioids
Lewis S. Nelson

A7 Opioid Antagonists
Mary Ann Howland

39. Dieting Agents and Regimens
Christine Haller

40. Iron
Jeanmarie Perrone

A8 Deferoxamine
Mary Ann Howland

41. Vitamins
Beth Y. Ginsberg

42. Essential Oils
S. Eliza Halcomb

43. Herbal Preparations
Oliver L. Hung and Neal A. Lewin

44. Athletic "Performance Enhancers"
Susi U. Vassallo

45. Food "Poisoning"
Michael G. Tunik

46. Botulism
Lewis R. Goldfrank and Neal E. Flomenbaum

A9 Botulinum Antitoxin
Lewis R. Goldfrank

47. Anticonvulsants
Suzanne Doyon

A10L-Carnitine
Mary Ann Howland

48. Antidiabetics and Hypoglycemics
George M. Bosse

A11Dextrose
Larissa I. Velez and Kathleen A. Delaney

A12 Octreotide
Mary Ann Howland

49. Thyroid and Antithyroid Medications
Nicole C. Bouchard

50. Antihistamines and Decongestants
Anthony J. Tomassoni and Richard S. Weisman

A13 Physostigmine Salicylate
Mary Ann Howland

51. Antimigraine Medications
Jason Chu and Neal A. Lewin

52. Antineoplastics
Richard Y. Wang

A14 Leucovorin (Folinic Acid) and Folic Acid
Mary Ann Howland

53. Pharmaceutical Additives
Sean P. Nordt and Lisa E. Vivero

54. Antibiotics, Antifungals and Antivirals
Christine M. Stork

55. Antituberculous Medications
Edward W. Boyer

A15 Pyridoxine
Mary Ann Howland

56. Antimalarials
G. Randall Bond

57. Anticoagulants
Mark Su and Robert S. Hoffman

A16 Vitamin K1
Mary Ann Howland

A17 Protamine
Mary Ann Howland

58. Calcium Channel Blockers
Francis DeRoos

59. ßeta-Adrenergic Antagonists
Jeffrey R. Brubacher

A18Glucagon
Mary Ann Howland

60. Other Antihypertensives
Francis DeRoos

61. Antidysrhythmics
Neal A. Lewin and Lewis S. Nelson

62. Cardioactive Steroids
Jason B. Hack and Neal A. Lewin

A19Digoxin-Specific Antibody Fragments (Fab)
Mary Ann Howland

63. Methylxanthines and Selective b2 Adrenergic Agonists
Robert J. Hoffman

64. Local Anesthetics
David R. Schwartz and Brian Kaufman

65. Inhalational Anesthetics
Brian Kaufman and Martin Griffel

66. Neuromuscular Blockers
Kenneth M. Sutin, Brian Kaufman, and Sanford M. Miller

A20 Dantrolene Sodium
Kenneth M. Sutin, Brian Kaufman, and Sanford M. Miller

67. Antipsychotics
David N. Juurlink

68. Lithium
Howard A. Greller

69. Monoamine Oxidase Inhibitors
Lada Kokan

70. Serotonin Reuptake Inhibitors and Atypical Antidepressants
Christine M. Stork

71. Cyclic Antidepressants
Erica L. Liebelt

72. Sedative-Hypnotics
David C. Lee

A21 Flumazenil
Mary Ann Howland

73. Amphetamines
William K. Chiang

74. Cocaine
Robert S. Hoffman

75. Ethanol
Luke Yip

A22 Thiamine Hydrochloride
Robert S. Hoffman

76. Ethanol Withdrawal
Jeffrey A. Gold and Lewis S. Nelson

77. Disulfiram and Disulfiramlike Reactions
Edwin K. Kuffner

78. Gamma Hydroxybutyric Acid and Analogs
Lawrence S. Quang

79. Inhalants
Heather Long

80. Hallucinogens
Kavita Babu and Robert P. Ferm

81. Cannabinoids
Michael McGuigan

82. Nicotine and Tobacco Preparations
Morton E. Salomon

83. Phencyclidine and Ketamine
Ruben Olmedo

84. Antimony
Asim F. Tarabar

85. Arsenic
Marsha D. Ford

A23 Dimercaprol (British Anti Lewisite or BAL)
Mary Ann Howland

86. Bismuth
Rama B. Rao

87. Cadmium
Stephen J. Traub and Robert S. Hoffman

88. Chromium
Steven B. Bird

89. Cobalt
Gar Ming Chan

90. Copper
Lewis S. Nelson

91. Lead
Fred M. Henretig

A24 Succimer (2,3-Dimercaptosuccunic Acid)
Mary Ann Howland

A25 Edetate Calcium Disodium (CaNa2 EDTA)
Mary Ann Howland

92. Mercury
Young-Jin Sue

93. Nickel
John Curtis and Michael I. Greenberg

94. Selenium
Diane P. Calello

95. Silver
Melisa W. Lai and Michele Burns Ewald

96. Thallium
Maria Mercurio Zappala and Robert S. Hoffman

A26 Prussian Blue
Maria Mercurio Zappala and Robert S. Hoffman

97. Zinc
Michele Burns Ewald

98. Antiseptics, Disinfectants, and Sterilants
Paul M. Wax

99. Camphor and Moth Repellents
Edwin K. Kuffner

100. Caustics
Jessica A. Fulton and Rama B. Rao

101. Hydrofluoric Acid and Fluorides
Mark Su

A27 Calcium
Mary Ann Howland

102. Hydrocarbons
David D. Gummin and Daniel O. Hryhorczuk

103. Toxic Alcohols
Sage W. Weiner

A28 Fomepizole
Mary Ann Howland

A29 Ethanol
Mary Ann Howland

104. Pesticides: An Overview with a Focus on Principles and Rodenticides
Neal E. Flomenbaum

105. Barium
Andrew Dawson

106. Sodium Monofluoroacetate and Fluoroacetamide
Fermin Barrueto

107. Phosphorus
Heikki E. Nikkanen and Michele Burns Ewald

108. Strychnine
Yiu-Cheung Chan

109. Insecticides: Organic Phosphorus Compounds and Carbamates
Richard F. Clark

A30 Pralidoxime
Mary Ann Howland

A31Atropine
Mary Ann Howland

110. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and DEET
Michael G. Holland

111. Herbicides
Rebecca L. Tominack

112. Methyl Bromide and Other Fumigants
Keith K. Burkhart

113. Mushrooms (Chapter113 (242.0K) )
Lewis R. Goldfrank

114. Plants
Mary Palmer and Joseph M. Betz (Chapter114 (336.0K) )

115. Arthropods
In-Hei Hahn and Neal A. Lewin (Chapter115 (296.0K) , Chapter115a (87.0K) )

A32 Antivenom (Scorpion and Spider)
Jeffrey Bernstein

116. Marine Envenomations (Chapter116 (159.0K) )
D. Eric Brush

117. Snakes and Other Reptiles (Chapter117 (629.0K) )
Bradley D. Riley, Anthony F. Pizon, Anne-Michelle Ruha, James R. Roberts and Edward J. Otten

A33 Antivenom (Crotaline and Elapid)
Anthony F. Pizon, Bradley D. Riley, Anne-Michelle Ruha, James R. Roberts and Edward J. Otten

118. Industrial Poisoning: Information and Control
Peter H. Wald

119. Simple Asphyxiants and Pulmonary Irritants
Lewis S. Nelson

120. Carbon Monoxide
Christian Tomaszewski

A34 Hyperbaric Oxygen
Stephen R. Thom

121. Cyanide and Hydrogen Sulfide
Christopher P. Holstege, Gary E. Isom and Mark A. Kirk

A35 Sodium and Amyl Nitrites
Mary Ann Howland

A36 Sodium Thiosulfate
Mary Ann Howland

A37 Hydroxocobalamin
Mary Ann Howland

122. Methemoglobin Inducers
Dennis Price

A38 Methylene Blue
Mary Ann Howland

123. Smoke Inhalation
Christopher P. Holstege and Mark A. Kirk

124. Risk Assessment and Risk Communication
Charles McKay

125. Hazmat Incident Response
Frank G. Walter

126. Chemical Weapons
Jeffrey R. Suchard

127. Biological Weapons
Jeffrey R. Suchard

128. Radiation
Joseph Rella

Section II. Poison Centers and Epidemiology

129. Poison Prevention and Education
Lauren Schwartz

130. Poison Information Centers and Poison Epidemiology
Robert S. Hoffman

131. International Perspectives in Medical Toxicology
Aaron Hexdall and Michael Eddleston

132. Principles of Epidemiology and Research Design
Kevin C. Osterhoudt

133. Adverse Drug Events and Postmarketing Surveillance
Louis R. Cantilena, Jr.

134. Medications, Errors, and Patient Safety
Pat Croskerry

135. Risk Management and Legal Principles
Barbara M. Kirrane and Dainius A. Drukteinis

Study Guide

Case Studies with Answers

Study Questions with Answers

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Goldfranks Toxicologix Emergencies