Site MapHelpFeedbackUse of Vasopressors and Inotropes in the Pharmacotherapy of Shock
Use of Vasopressors and Inotropes in the Pharmacotherapy of Shock



1

Conditions that can result in a lowering of blood pressure in critically ill patients include:
A)Decreased cardiac output
B)Decreased pulmonary capillary wedge pressure
C)Systemic vasodilation
D)All the above
E)None of the above
2

The central venous pressure (CVP) catheter is a device that is used to effectively perform what function in critically ill patients?
A)Obtain venous blood samples
B)Administer drugs directly into the central circulation
C)Accurately determine blood volume
D)A and B only
E)All the above
3

Which of the following statements about mixed-venous oxygen saturation is correct?
A)Indirectly measures oxygen extraction by tissues
B)Is often low in inadequately volume-resuscitated patients with septic shock
C)More accurately measures adequacy of volume resuscitation than does blood pressure measurement
D)Should be targeted to a value in excess of 70%
E)All the above
4

A parameter that determines the effect of therapy on regional perfusion is
A)Arterial blood lactate concentration
B)Arterial gastric mucosal PCO2 gap
C)Oxygen delivery
D)Oxygen consumption
E)Systemic vascular resistance
5

Stimulation of the ?-adrenergic receptor by agonists results in a physiologic response mediated by:
A)Inositoltrisphosphate
B)Cyclic AMP
C)Cyclic GMP
D)Intramucosal pHi
E)Nitric oxide
6

Which of the following drugs stimulates only ?-adrenergic receptors?
A)Dobutamine
B)Dopamine
C)Phenylephrine
D)Epinephrine
E)Norepinephrine
7

A drug with primary ß1-adrenergic receptor activity and mild ß2 and a1 activity that exists as a racemic mixture is:
A)Dobutamine
B)Dopamine
C)Phenylephrine
D)Epinephrine
E)Norepinephrine
8

Which of the following outcomes are goals of early goal-directed therapy (EGDT)?
A)CVP of 8 to 12 mm Hg
B)MAP greater than 65 mm Hg
C)ScvO2 greater than 70%
D)Hematocrit greater than 30%
E)All the above
9

Development of lactic acidosis by a vasopressor catecholamine is caused by:
A)Enhanced vasoconstriction in peripheral arteries
B)Enhanced glycogenolysis
C)Mobilization of lactate from peripheral tissues
D)A and B only
E)All the above
10

Extravasation of a vasopressor catecholamine can be treated pharmacologically with intradermal injections of:
A)Phentolamine
B)Phenylephrine
C)Nitric oxide
D)Vasopressin
E)None of the above
11

Which of the following catecholamines is associated with a transient decrease in intramucosal pHi and transient increase in blood lactate concentration during treatment?
A)Dobutamine
B)Dopamine
C)Phenylephrine
D)Epinephrine
E)Norepinephrine
12

A preferred catecholamine to treat hypotension in a septic shock patient with concomitant tachycardia is:
A)Dobutamine
B)Dopamine
C)Phenylephrine
D)Epinephrine
E)Norepinephrine
13

Which of the following outcomes are associated with vasopressin use in septic shock?
A)Increased urine production
B)Increased blood pressure
C)Dose reduction of other vasopressors (catecholamines)
D)A and B only
E)All of the above
14

Which of the following is true about low-dose dopamine?
A)Plasma concentrations are predictable at various dosages
B)It results in an increase in mucosal perfusion and higher pHi
C)It has no effect on reducing the incidence of acute renal failure
D)Extravasation does not result in tissue sloughing
E)Dopamine is derived from enzymatic oxidation of arginine
15

Which adverse drug effect is not seen with dobutamine?
A)Tachycardia
B)Bradycardia
C)Hypotension
D)Decreased cardiac index
E)Decreased splanchnic oxygen delivery
16

Which of the following scenarios warrants the consideration of corticosteroid therapy in septic shock?
A)Cortisol increase of >9 mcg/dL after adrenocorticotropic hormone stimulation test
B)Refractory hypotension to vasopressors
C)ScvO2 less than 70%
D)A and B only
E)All of the above





We welcome your feedback. Please send comments and questions to: medical_education@mcgraw-hill.com.
To learn more about the book this website supports, please visit its Information Center.
(c)2008 McGraw-Hill Professional
Any use is subject to the Terms of Use and Privacy Notice.
McGraw-Hill Professional is one of the many fine businesses of The McGraw-Hill Companies.


Pharmacotherapy 7th EditionOnline Learning Center

Home > Chapter 25 > Self-Assessment Quiz