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1 |  |  Which of the following amino acids has an amide side chain? |
|  | A) | aspartic acid |
|  | B) | glutamic acid |
|  | C) | asparagine |
|  | D) | methionine |
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2 |  |  Which of the following amino acids is achiral? |
|  | A) | alanine |
|  | B) | glycine |
|  | C) | serine |
|  | D) | cysteine |
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3 |  |  Which of the following amino acids does NOT have an aromatic ring? |
|  | A) | tyrosine |
|  | B) | histidine |
|  | C) | tryptophan |
|  | D) | proline |
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4 |  |  Which of the following ionic structures is NOT reasonable for histidine?
 (22.0K) |
|  | A) |  (19.0K) |
|  | B) |  (18.0K) |
|  | C) |  (18.0K) |
|  | D) |  (19.0K) |
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5 |  |  Which compound is an intermediate in the Strecker synthesis (RCHO, HCN, NH3) of amino acids?
 (17.0K) |
|  | A) | a |
|  | B) | b |
|  | C) | c |
|  | D) | d |
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6 |  |  How would you accomplish the following synthesis of aspartic acid?
 (15.0K) |
|  | A) | 1. NH3, HCN
2. H3O+, H2O, heat
3. NaOH
4. Neutralize |
|  | B) | 1. NH3
2. H3O+, H2O, heat |
|  | C) | 1. HCN
2. NH3
3. H3O+, H2O, heat
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|  | D) | 1. NH3, HCN
2. H3O+, H2O, heat |
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7 |  |  What is the product of the following synthesis?
 (14.0K) |
|  | A) |  (15.0K) |
|  | B) |  (14.0K) |
|  | C) |  (15.0K) |
|  | D) |  (14.0K) |
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8 |  |  Which of the following structures is NOT a dipeptide? |
|  | A) |  (16.0K) |
|  | B) |  (20.0K) |
|  | C) |  (19.0K) |
|  | D) |  (17.0K) |
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9 |  |  The following peptide is hydrolyzed under strong acidic conditions. What are the products of the reaction?
 (24.0K) |
|  | A) |  (24.0K) |
|  | B) |  (26.0K) |
|  | C) |  (24.0K) |
|  | D) |  (22.0K) |
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10 |  |  A tripeptide contains glycine, alanine, and serine. How many different sequences are possible? |
|  | A) | 3 |
|  | B) | 4 |
|  | C) | 5 |
|  | D) | 6 |
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11 |  |  Which of the following is NOT a part of the primary protein structure? |
|  | A) | the amino acid sequence |
|  | B) | the disulfide linkages |
|  | C) | the planar nature of the amide linkage |
|  | D) | the conformation of the polypeptide backbone |
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12 |  |  Which of the following is the correct structure of the tripeptide Gly–Phe–Ala? |
|  | A) |  (15.0K) |
|  | B) |  (14.0K) |
|  | C) |  (14.0K) |
|  | D) |  (15.0K) |
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13 |  |  Which of the following statements about the conformation (secondary and tertiary structure) of proteins is FALSE? |
|  | A) | The four atoms of an amide linkage (–CO–NH–) lie in a plane as a result of resonance between the nitrogen and the carbonyl group. |
|  | B) | Electrostatic attraction occurs between basic and acidic side chains. |
|  | C) | The favored conformation of a protein is always that which has the greatest number of hydrogen bonds. |
|  | D) | The presence of the amino acid proline has the effect of turning a corner in a protein. |
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14 |  |  Which of the following statements about the arrangement of a protein in three dimensions is FALSE? |
|  | A) | As a result of hydrogen bonding, a portion of a protein may exist as a right-handed α-helix with 3.6 amino acid residues per turn, and a repeat unit of 5.4 Å. |
|  | B) | As a result of hydrogen bonding a portion of a protein may exist as a pleated sheet, in which the repeat unit is 7.0 Å. |
|  | C) | In a pleated sheet, the polyamide chains may be parallel or antiparallel. |
|  | D) | A portion of a protein may exist as a flat sheet with a repeat unit of 7.2 Å. |
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15 |  |  Which of the following is NOT an example of secondary structure found in proteins? |
|  | A) | β-pleated sheet |
|  | B) | α-helix |
|  | C) | hydrophobic folding |
|  | D) | random coil |
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16 |  |  What does the quaternary structure of a protein involve? |
|  | A) | the association of two or more peptide chains |
|  | B) | the complete three-dimensional conformation |
|  | C) | partial denaturation |
|  | D) | random coil alternating with α-helix |
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17 |  |  Which of the following is not considered part of the tertiary structure of proteins? |
|  | A) | the hydrophobic effect |
|  | B) | the restricted rotation in amide bonds |
|  | C) | the electrostatic interactions |
|  | D) | the hydrogen bonds |
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18 |  |  Which of the following statements about an enzyme is FALSE? |
|  | A) | An enzyme is usually a large protein. |
|  | B) | An enzyme is a catalyst for biological reactions. |
|  | C) | An enzyme is a chiral molecule. |
|  | D) | An enzyme changes the equilibrium constant of a reaction. |
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19 |  |  What is the main function of enzymes in biological systems? |
|  | A) | catalysis of a reaction |
|  | B) | altering the equilibrium of a reaction |
|  | C) | energy transport |
|  | D) | protein sysnthesis |
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