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1 | | Which of the following amino acids has an amide side chain? |
| | A) | aspartic acid |
| | B) | glutamic acid |
| | C) | asparagine |
| | D) | methionine |
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2 | | Which of the following amino acids is achiral? |
| | A) | alanine |
| | B) | glycine |
| | C) | serine |
| | D) | cysteine |
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3 | | Which of the following amino acids does NOT have an aromatic ring? |
| | A) | tyrosine |
| | B) | histidine |
| | C) | tryptophan |
| | D) | proline |
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4 | | Which of the following ionic structures is NOT reasonable for histidine? (22.0K) |
| | A) | (19.0K) |
| | B) | (18.0K) |
| | C) | (18.0K) |
| | D) | (19.0K) |
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5 | | Which compound is an intermediate in the Strecker synthesis (RCHO, HCN, NH3) of amino acids? (17.0K) |
| | A) | a |
| | B) | b |
| | C) | c |
| | D) | d |
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6 | | How would you accomplish the following synthesis of aspartic acid?
(15.0K) |
| | A) | 1. NH3, HCN
2. H3O+, H2O, heat
3. NaOH
4. Neutralize |
| | B) | 1. NH3
2. H3O+, H2O, heat |
| | C) | 1. HCN
2. NH3
3. H3O+, H2O, heat
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| | D) | 1. NH3, HCN
2. H3O+, H2O, heat |
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7 | | What is the product of the following synthesis? (14.0K) |
| | A) | (15.0K) |
| | B) | (14.0K) |
| | C) | (15.0K) |
| | D) | (14.0K) |
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8 | | Which of the following structures is NOT a dipeptide? |
| | A) | (16.0K) |
| | B) | (20.0K) |
| | C) | (19.0K) |
| | D) | (17.0K) |
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9 | | The following peptide is hydrolyzed under strong acidic conditions. What are the products of the reaction? (24.0K) |
| | A) | (24.0K) |
| | B) | (26.0K) |
| | C) | (24.0K) |
| | D) | (22.0K) |
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10 | | A tripeptide contains glycine, alanine, and serine. How many different sequences are possible? |
| | A) | 3 |
| | B) | 4 |
| | C) | 5 |
| | D) | 6 |
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11 | | Which of the following is NOT a part of the primary protein structure? |
| | A) | the amino acid sequence |
| | B) | the disulfide linkages |
| | C) | the planar nature of the amide linkage |
| | D) | the conformation of the polypeptide backbone |
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12 | | Which of the following is the correct structure of the tripeptide Gly–Phe–Ala? |
| | A) | (15.0K) |
| | B) | (14.0K) |
| | C) | (14.0K) |
| | D) | (15.0K) |
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13 | | Which of the following statements about the conformation (secondary and tertiary structure) of proteins is FALSE? |
| | A) | The four atoms of an amide linkage (–CO–NH–) lie in a plane as a result of resonance between the nitrogen and the carbonyl group. |
| | B) | Electrostatic attraction occurs between basic and acidic side chains. |
| | C) | The favored conformation of a protein is always that which has the greatest number of hydrogen bonds. |
| | D) | The presence of the amino acid proline has the effect of turning a corner in a protein. |
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14 | | Which of the following statements about the arrangement of a protein in three dimensions is FALSE? |
| | A) | As a result of hydrogen bonding, a portion of a protein may exist as a right-handed α-helix with 3.6 amino acid residues per turn, and a repeat unit of 5.4 Å. |
| | B) | As a result of hydrogen bonding a portion of a protein may exist as a pleated sheet, in which the repeat unit is 7.0 Å. |
| | C) | In a pleated sheet, the polyamide chains may be parallel or antiparallel. |
| | D) | A portion of a protein may exist as a flat sheet with a repeat unit of 7.2 Å. |
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15 | | Which of the following is NOT an example of secondary structure found in proteins? |
| | A) | β-pleated sheet |
| | B) | α-helix |
| | C) | hydrophobic folding |
| | D) | random coil |
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16 | | What does the quaternary structure of a protein involve? |
| | A) | the association of two or more peptide chains |
| | B) | the complete three-dimensional conformation |
| | C) | partial denaturation |
| | D) | random coil alternating with α-helix |
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17 | | Which of the following is not considered part of the tertiary structure of proteins? |
| | A) | the hydrophobic effect |
| | B) | the restricted rotation in amide bonds |
| | C) | the electrostatic interactions |
| | D) | the hydrogen bonds |
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18 | | Which of the following statements about an enzyme is FALSE? |
| | A) | An enzyme is usually a large protein. |
| | B) | An enzyme is a catalyst for biological reactions. |
| | C) | An enzyme is a chiral molecule. |
| | D) | An enzyme changes the equilibrium constant of a reaction. |
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19 | | What is the main function of enzymes in biological systems? |
| | A) | catalysis of a reaction |
| | B) | altering the equilibrium of a reaction |
| | C) | energy transport |
| | D) | protein sysnthesis |
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