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  1. Introduction
    1. Anxiety, a state of fear, has three (3) basic components
      1. Subjective reports of tension, apprehension, dread
      2. Behavioral responses
      3. Physiological responses
    2. Anxiety disorders
      1. Characterized by manifest anxiety or behavior aimed at warding off anxiety
    3. Neurosis
      1. Historically seen as related to anxiety
    4. Anxiety disorders
      1. 1. The single largest mental health problem in United States
  2. Anxiety Disorder Syndromes
    1. Panic Disorder
      1. Panic attack characterized by sudden and unexpected anxiety
      2. Subjective report of derealization and depersonalization
      3. Disorder often first recognized by complaints of having heart attack
      4. Two kinds of panic attack
        1. Uncued attacks come out of the blue
        2. Cue attacks occur in response to situational trigger
      5. Stressful events common
      6. Complication is agoraphobia, which is fear of being in situation where escape is difficult
        1. Often preceded by panic attacks
        2. DSM-IV-TR lists agoraphobia as complication of panic disorder
      7. Panic attacks can be induced in lab using pharmacological agents
      8. Groups at risk
        1. Affects 3.5% of population; agoraphobia affects 5.3%
        2. Gender, age, and marital status are risk factors
        3. Similarity across ethnic groups and cultures, but symptoms vary
    2. Generalized Anxiety Disorder (GAD)
      1. Generalized anxiety disorder is chronic state of diffuse anxiety
      2. Common areas of worry include family, money, work, and health
      3. Generalized anxiety disorder is distinct from panic disorder
        1. Symptom profiles differ
        2. Has more gradual onset than panic disorder
        3. Run in families, but run separately
      4. Groups at risk
        1. Age at onset is early
        2. Gender and marital status are risk factors
        3. Similarity across cultures
    3. Phobias
      1. Phobias involve two factors
        1. Intense and persistent fear of object or situation that poses no real threat
        2. Avoidance of phobic situations
      2. Specific phobia
        1. Specific phobias involve acrophobia, claustrophobia, and animal phobias
        2. Most people can manage their specific phobia without much difficulty
      3. Social phobia
        1. Social phobia characterized by avoidance of performing certain actions in front of others for fear of embarrassing or humiliating oneself
        2. Common social phobias include public speaking, eating in public, and using public bathrooms
        3. Fears restrict choice and may interfere with work
        4. Social phobics have characteristics that make them prone to social rejection
        5. Social phobia is not specific phobia for social situations
        6. Distinguishing social phobia from other syndromes is difficult
        7. Social phobics recall themselves as being shy in childhood
        8. Groups at risk
          1. Often begin in childhood
          2. Affects up to 11% of population
          3. Gender, ethnicity, and SES are risk factors
    4. Obsessive-Compulsive Disorder (OCD)
      1. Obsession is thought or image that is intruding and irresistible
      2. Compulsion is action that is repeated again and again
      3. Obsessions are common in general populations, but pathological obsessions do not pass, are recurrent and involve scandalous or violent themes
      4. Compulsions generally related to duty and caution
        1. Cleaning rituals
        2. Checking rituals
      5. Can be completely disabling
      6. Individuals with obsessive-compulsive disorder generally do not show characteristics of obsessive-compulsive personality disorder
      7. Not related to problems of excess that are seen as means to an end
      8. Obsessive-compulsive disorder does overlap with depression
      9. Groups at risk
        1. Affects 2-3% of general population
        2. Marital status is a risk factor
        3. Females and males equally at risk
        4. Usually appears in late adolescence or early adulthood
        5. Onset may be related to stressful event
    5. Posttraumatic Stress Disorder (PTSD)
      1. Posttraumatic stress disorder is severe psychological reaction to traumatic events
      2. Source of stress is external event that is very traumatic
      3. Symptoms consist of heightened arousal, reactions to reminders of trauma, and numbing to surroundings
      4. Symptoms generally appear shortly after trauma, but there may be an extended time between event and onset of symptoms
      5. Combat can trigger disorder but is typically preceded by accumulated stress
      6. Victims of civilian catastrophes may also be related to posttraumatic stress disorder
      7. Those that escape a disaster may experience survivor's guilt
      8. Groups at risk
        1. Affects 8% of population
        2. Marital status, gender, ethnicity, and type of trauma are important
        3. Not all people are disabled by traumatic experiences because severity of trauma is significant
        4. Coping and attributional style related to reaction to trauma
        5. Environment to which individual returns to following trauma important
        6. Nature of trauma affects posttraumatic stress disorder and type of symptoms
      9. Problems in the classification of posttraumatic stress disorder
        1. In DSM-IV-TR, reactions to ordinary trauma are considered as adjustment disorders
        2. Most victims show symptoms of posttraumatic stress disorder
        3. There is disagreement regarding classifying posttraumatic stress disorder as an anxiety disorder
  3. Anxiety Disorders: Theory and Therapy
    1. The Psychodynamic Perspective: Neurosis
      1. The Roots of Neurosis
        1. Anxiety is viewed as coming from external danger and breakdowns of ego attempt to satisfy id without violating demands of reality and superego resulting in neurosis
        2. Anxiety chronically experienced is generalized anxiety disorder
        3. Anxiety builds up in panic disorder as id impulses move closer to the conscious mind
        4. In phobia, ego defends against anxiety by displacing it
        5. Symptoms of obsessive-compulsive disorder affect its explanation
        6. Bowlby's attachment theory suggests that disturbances in parent-child relationship may lead to anxiety disorder
      2. Treating Neurosis
        1. Goal is to expose, and neutral material ego is defending against
        2. Free association, dream analysis, resistance, and transference used to reveal unconscious material
        3. Therapy moving toward briefer, face-to-face therapies directed more to present and specific symptoms
    2. The Behavioral Perspective: Learning to Be Anxious
      1. How We Learn Anxiety
        1. Avoidance learning has two components
          1. Respondent learning changing neutral stimulus to anxiety-arousing
          2. Avoidance of conditioned stimulus resulting in relief from anxiety
        2. Disorders are variations on avoidance-reinforced anxiety
        3. Research supports avoidance-learning theory but has several problems
          1. Some anxiety patients do report conditioning, some do not
          2. Traditional learning theory has difficulty explaining why very select, nonrandom types of stimuli become phobic objects
          3. Focus entirely on concrete stimuli and observable behaviors and not thoughts
        4. Cognitive processes play important role in anxiety such as efficacy expectations and fear of fear
      2. Unlearning Anxiety
        1. Confrontation with feared stimulus
        2. Systematic desensitization involves hierarchy of fears and relaxation
        3. Systematic desensitization effective with specific phobias
          1. Relaxation unnecessary
          2. Exposure with feared stimulus effective
          3. Imagined exposure with feared stimulus is flooding
          4. Exposure effective with anxiety disorders
        4. More complex anxiety disorders may require combinations of different cognitive techniques
    3. The Cognitive Perspective: Overestimation of Threat
      1. Anxiety as Overestimation (misperception)
        1. People with anxiety disorders misperceive or misinterpret stimuli: internal, and external
        2. Panic disorder patients interpret bodily sensations as dangerous and continue to pay even closer attention to internal sensations
          1. Some research supports model
          2. Model doesn't explain why panic attacks occurring during sleep are often not connected with dreams and some patients report catastrophic conditions after attack
        3. Agoraphobia seen as extension of panic disorder where person appraises that he cannot cope with panic
        4. Other anxiety disorders seen as variations on misinterpretation-of-threat theme
      2. Reducing Perceptions of Threat
        1. Focus is on panic attack itself rather than on avoidance behavior
        2. Therapy involves three components
          1. Identify patient's negative interpretations of bodily sensations
          2. Suggest alternative interpretations
          3. Help patient test validity of alternative interpretation
        3. Therapy has been successful at helping most patients to remain free of panic attacks
        4. Questions remain on why therapy works; suggestions include exposure
        5. Generalized anxiety disorder treated with combined cognitive and behavioral therapy
    4. The Neuroscience Perspective: Biochemistry and Medicine
      1. Genetic Research
        1. Panic disorder has genetic basis; other disorders have weaker but significant genetic bias, with generalized anxiety disorder having weakest evidence
        2. A general vulnerability is inherited toward anxiety disorders in general rather than toward specific disorder
      2. The Role of Neurotransmitters
        1. Anxiety disorders involve GABA, which is an inhibitory neurotransmitter; it is affected by benzodiazepines
        2. Panic disorder responsive to antidepressants suggesting another mechanism
          1. Chemical basis of panic disorder differs from generalized anxiety
          2. Panic disorder may be closely related to depression
        3. Panic attacks may be triggered by increased activity in locus ceruleus
        4. Another model of panic disorder is called suffocation false alarm hypothesis; some individuals have hypersensitive monitors and produce false alarm
        5. Obsessive-compulsive disorder related to serotonin abnormalities and the basal ganglia
        6. Little is known about the biology of social phobia, but may involve serotonin abnormalities
        7. Posttraumatic stress disorder may be explained by a hormonal theory suggesting hormones affect memory of trauma to the point that memory cannot fade
      3. Minor Tranquilizers
        1. Minor tranquilizers are used to reduce anxiety
        2. Benzodiazepines are very popular minor tranquilizers
          1. Are CNS depressants
          2. Can lead to dose-dependent side effects such as daytime sedation, memory disturbances
          3. Withdrawal from benzodiazepines is a drawback and may be followed by rebound as is case of Xanax
          4. Short-acting and long-acting benzodiazepines have differing pattern of withdrawal
      4. Antidepressant Drugs
        1. Antidepressant drugs used to elevate mood
        2. Effective for panic disorder and obsessive-compulsive disorder
        3. MAO inhibitors interfere with action of enzyme MAO
          1. Effective treatment for anxiety disorders
          2. Can have adverse effects on brain, liver, and cardiovascular system
        4. Tricyclics effective with panic disorder and obsessive-compulsive disorder, but with side effects
        5. Selective serotonin reuptake inhibitors (SSRIs) block serotonin reuptake
          1. Prozac is most widely prescribed antidepressant
          2. Prozac works well with social phobia, panic disorder, and obsessive-compulsive disorder
          3. SSRI can have side effects
        6. Critics of antianxiety drugs suggest that drugs allow people to avoid their problems
          1. Solution appears to be psychotherapy and drugs
          2. Some success with combined psychotherapy and drugs has been seen with panic disorder, but less clear with other anxiety disorders







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