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| 1 |  |  General functions of the lymphatic system include |
|  | A) | fluid and nutrient transport |
|  | B) | lymphocyte development |
|  | C) | the immune response |
|  | D) | all of the above |
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| 2 |  |  How much excess interstitial fluid must the lymphatic system return to the bloodstream each day? |
|  | A) | less than 500 milliliters |
|  | B) | up to 1 liter |
|  | C) | about 3 liters |
|  | D) | between 4 and 5 liters |
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| 3 |  |  Which selection includes all the major components of the lymphatic system? |
|  | A) | lymphatic cells and structures, lymph, and lymph vessels |
|  | B) | thoracic duct, right lymphatic duct, and lymph |
|  | C) | lymphocytes, lymph, and lymph nodes |
|  | D) | spleen, thymus, and tonsils |
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| 4 |  |  A systematic defense against antigens, initiated by lymphatic cells, is called |
|  | A) | a cross-reaction |
|  | B) | inflammation |
|  | C) | septicemia |
|  | D) | an immune response |
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| 5 |  |  Which one of the following statements is false? |
|  | A) | blood pressure forces fluid out of capillaries into the interstitial spaces |
|  | B) | "leaked" fluids can be returned to the blood only by lymphatic vessels |
|  | C) | lymphatic vessels return excess interstitial fluid to the venous circulation |
|  | D) | blood volume would drop precipitously without the lymphatic drainage |
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| 6 |  |  Which of the following is false in comparing lymphatic vessels with small veins? |
|  | A) | both have valves within the lumen |
|  | B) | both contain the same three tunics |
|  | C) | pressures in lymphatic vessels exceed those in veins |
|  | D) | contraction of nearby skeletal muscles helps propel fluids through both |
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| 7 |  |  The two largest lymph-collecting vessels are the |
|  | A) | cisterna chyli and thoracic duct |
|  | B) | thoracic duct and right lymphatic duct |
|  | C) | left subclavian trunk and right lymphatic duct |
|  | D) | left jugular trunk and right subclavian trunk |
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| 8 |  |  Which sequence correctly traces the flow of lymph from lymphatic capillaries in the right thigh to the left subclavian vein? |
|  | A) | lymphatic vessels, lymphatic trunks, cisterna chyli, thoracic duct |
|  | B) | cisterna chyli, lymphatic vessels, lymphatic trunks, thoracic duct |
|  | C) | femoral lymphatic vessels, right lymphatic duct, thoracic duct |
|  | D) | right lymphatic duct, lumbar lymphatic vessels, thoracic duct |
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| 9 |  |  Lymphatic cells include all of the following except |
|  | A) | macrophages |
|  | B) | dendritic cells |
|  | C) | neutrophils |
|  | D) | lymphocytes |
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| 10 |  |  T-lymphocytes mature in the ____________, while B-lymphocytes mature in the ____________. |
|  | A) | yellow bone marrow; red bone marrow |
|  | B) | thyroid follicles; bone marrow |
|  | C) | bone marrow; thymus |
|  | D) | thymus; bone marrow |
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| 11 |  |  All of the following are types of T-lymphocytes except |
|  | A) | helper |
|  | B) | plasma |
|  | C) | suppressor |
|  | D) | memory |
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| 12 |  |  About 70-85% of the body's lymphocytes are |
|  | A) | T-lymphocytes |
|  | B) | plasma cells |
|  | C) | NK cells |
|  | D) | B-lymphocytes |
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| 13 |  |  Which lymphocytes initiate and oversee the immune response? |
|  | A) | memory B-lymphocytes |
|  | B) | helper T-lymphocytes |
|  | C) | cytotoxic T-lymphocytes |
|  | D) | natural killer cells |
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| 14 |  |  Helper T-lymphocytes secrete chemical signals called ____________ that bind to receptors on other lymphatic cells and activate them. |
|  | A) | coreceptors |
|  | B) | antibodies |
|  | C) | immunoglobulins |
|  | D) | cytokines |
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| 15 |  |  Each type of T-lymphocyte has a particular ____________ in its plasma membrane that recognizes a specific antigen. |
|  | A) | surface antibody |
|  | B) | coreceptor |
|  | C) | alpha-receptor |
|  | D) | beta-receptor |
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| 16 |  |  Plasma cells produce and secrete |
|  | A) | antibodies |
|  | B) | antigens |
|  | C) | cytokines |
|  | D) | alpha-globulins |
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| 17 |  |  Which one of the following would respond to multiple antigens? |
|  | A) | cytotoxic T-lymphocyte |
|  | B) | memory T-lymphocyte |
|  | C) | NK cell |
|  | D) | plasma cell |
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| 18 |  |  Lymphopoiesis, the process of lymphocyte development and maturation, occurs in |
|  | A) | the spleen and liver |
|  | B) | red bone marrow |
|  | C) | the thymus |
|  | D) | both b and c |
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| 19 |  |  A fully mature lymphocyte that is ready to participate in the immune response is said to be |
|  | A) | immunocompromised |
|  | B) | immunocompetent |
|  | C) | antigenically primed |
|  | D) | facilitated |
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| 20 |  |  Oval clusters of lymphatic cells with some extracellular matrix but no connective tissue capsule are called |
|  | A) | lymph nodes |
|  | B) | lymphatic sinuses |
|  | C) | lymphatic nodules |
|  | D) | medullary sinuses |
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| 21 |  |  The large clusters of lymphatic nodules found in the throat are called |
|  | A) | Peyer patches |
|  | B) | tonsils |
|  | C) | lymph nodes |
|  | D) | lymph glands |
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| 22 |  |  Large groups of lymphatic nodules in the mucosa of the gastrointestinal, respiratory, genital, and urinary tracts are collectively called |
|  | A) | MALT |
|  | B) | Peyer patches |
|  | C) | germinal centers |
|  | D) | mucosal lymph nodes |
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| 23 |  |  Which set includes only lymphatic organs? |
|  | A) | lymphatic nodules, tonsils, Peyer patches |
|  | B) | thymus, lymph nodes, spleen |
|  | C) | lymph nodes, tonsils, MALT |
|  | D) | tonsils, spleen, thymus |
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| 24 |  |  Clusters of lymph nodes are found in which of the following body regions? |
|  | A) | axillary |
|  | B) | cervical |
|  | C) | inguinal |
|  | D) | all of the above |
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| 25 |  |  The thymus is a lymphatic organ that |
|  | A) | is divided into four lobes by its connective tissue capsule |
|  | B) | reaches a maximum weight of 30-50 grams at puberty |
|  | C) | is located in the posterior mediastinum, inferior to the heart |
|  | D) | remains functional throughout adulthood, especially after age 40 |
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| 26 |  |  Several thymic hormones are secreted by ____________ in the cortex of the thymus. |
|  | A) | nurse cells |
|  | B) | thymic corpuscles |
|  | C) | trabeculae |
|  | D) | macrophages |
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| 27 |  |  What occurs in the thymus? |
|  | A) | production of large quantities of antibodies |
|  | B) | activation of the immune response by circulating antigens |
|  | C) | T-lymphocyte maturation and differentiation |
|  | D) | all of the above |
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| 28 |  |  The spleen performs which of the following functions? |
|  | A) | initiates an immune response when antigens are detected in the blood |
|  | B) | stores erythrocytes and platelets and hemolyzes old, defective ones |
|  | C) | phagocytizes bacteria and foreign debris from the blood |
|  | D) | all of the above |
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| 29 |  |  Which one of the following does not accurately describe the spleen? |
|  | A) | surrounded by a capsule composed of dense irregular connective tissue |
|  | B) | divided into an outer cortex and an inner medulla by fibrous trabeculae |
|  | C) | white pulp contains clusters of lymphatic cells encircling central arteries |
|  | D) | red pulp contains splenic cords and sinusoids with numerous macrophages |
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| 30 |  |  With advancing age the lymphatic system loses effectiveness in |
|  | A) | providing immunity and fighting disease |
|  | B) | transporting lymph to the bloodstream |
|  | C) | absorbing dietary lipids from the small intestine |
|  | D) | all of the above |
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