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| 1 |  |  Which of the following tissues is found in the fewest body locations? |
|  | A) | fibrocartilage |
|  | B) | elastic cartilage |
|  | C) | cortical bone |
|  | D) | trabecular bone |
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| 2 |  |  During early embryonic development, cartilage grows both internally and along its periphery. The former is called ____________ growth; the latter, ____________. |
|  | A) | appositional; interstitial |
|  | B) | interstitial; appositional |
|  | C) | osteogenic; chondrogenic |
|  | D) | chondrogenic; osteogenic |
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| 3 |  |  One of the main differences between the two growth patterns of cartilage is the source of new |
|  | A) | chondroblasts |
|  | B) | chondrocytes |
|  | C) | cartilage matrix |
|  | D) | perichondrium |
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| 4 |  |  Why does all growth normally cease in mature cartilage? |
|  | A) | the matrix of mature cartilage is not able to expand |
|  | B) | cartilage has no blood supply and thus no energy source for growth |
|  | C) | once mature, cartilage is converted to bone by endochondral ossification |
|  | D) | both a and b |
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| 5 |  |  Chondrocytes die and stem cells in the perichondrium form osteoblasts during which of these processes? |
|  | A) | appositional growth of cartilage |
|  | B) | interstitial growth of bone |
|  | C) | intramembranous ossification |
|  | D) | endochondral ossification |
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| 6 |  |  Calcification occurs in ____________ during dermal ossification but in ____________ during endochondral ossification. |
|  | A) | the dermis; hyaline cartilage |
|  | B) | mesenchyme; fibrocartilage |
|  | C) | osteoid; hyaline cartilage |
|  | D) | osteoid; fibrocartilage |
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| 7 |  |  A layer of dense irregular connective tissue typically covers all of the following except |
|  | A) | hyaline cartilage |
|  | B) | fibrocartilage |
|  | C) | elastic cartilage |
|  | D) | compact bone |
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| 8 |  |  Which of the following is not a function of periosteum? |
|  | A) | anchors blood vessels and nerves to the surface of the bone |
|  | B) | isolates and protects the bone from surrounding structures |
|  | C) | provides a smooth surface for articulation between bones |
|  | D) | participates in appositional bone growth and fracture repair |
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| 9 |  |  Osteons are to dense bone as ____________ are to cancellous bone. |
|  | A) | trabeculae |
|  | B) | interstitial lamellae |
|  | C) | parallel lamellae |
|  | D) | canaliculi |
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| 10 |  |  By interconnecting the lacunae and the blood supply, ____________ allow osteocytes to transfer nutrients and wastes through an otherwise impenetrable solid matrix. |
|  | A) | perforating canals |
|  | B) | canaliculi |
|  | C) | central canals |
|  | D) | lamellae |
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| 11 |  |  Arrange the following from lowest to highest in terms of their contribution to the mass of bone tissue: (1) collagen fibers; (2) osteocytes, osteoblasts, and osteoclasts; and (3) calcium phosphate. |
|  | A) | 1, 2, 3 |
|  | B) | 3, 1, 2 |
|  | C) | 2, 1, 3 |
|  | D) | 2, 3, 1 |
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| 12 |  |  What change in physical structure would result from an excess of organic components relative to the amount of hydroxyapatite in the matrix of a bone? |
|  | A) | greater rigidity |
|  | B) | greater strength |
|  | C) | decreased flexibility |
|  | D) | increased flexibility |
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| 13 |  |  A major difference between compact and spongy bone is that |
|  | A) | spongy bone forms only from mesenchyme |
|  | B) | there are no osteons in spongy bone |
|  | C) | spongy bone contains no hydroxyapatite |
|  | D) | the trabeculae of compact bone are larger |
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| 14 |  |  During bone remodeling, if the rate of osteolysis exceeds the rate of osteogenesis, the bone becomes |
|  | A) | longer and thinner |
|  | B) | thicker along the shaft |
|  | C) | demineralized |
|  | D) | stronger |
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| 15 |  |  Under what circumstances does fibrocartilage normally ossify? |
|  | A) | endochondral ossification |
|  | B) | fracture repair |
|  | C) | lamellar bone formation |
|  | D) | interstitial growth |
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| 16 |  |  While eating fried chicken from a popular chain restaurant, David notices that the ends of the bones in the wing and drumstick are smooth, featureless, and covered with a thick cap of cartilage. What is the most likely explanation? |
|  | A) | articular cartilage is much thicker in chickens than in humans |
|  | B) | bird bones have completely different features from human bones |
|  | C) | the chicken was so young that the bones were not fully ossified |
|  | D) | none of the above |
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| 17 |  |  Lengthwise bone growth involves the final steps of |
|  | A) | osteoporosis and osteopenia |
|  | B) | fracture healing |
|  | C) | intramembranous ossification |
|  | D) | endochondral ossification |
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| 18 |  |  In interstitial bone growth, what happens when the zone of ossification overtakes the zone of resting cartilage? |
|  | A) | the epiphyseal plate becomes the epiphyseal line |
|  | B) | lengthwise growth of the bone terminates (at least at one end) |
|  | C) | the metaphysis converts from hyaline cartilage to bone |
|  | D) | all of the above |
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| 19 |  |  ____________ is a continual, hormonally controlled process that is essentially a race between osteoblasts and osteoclasts. |
|  | A) | appositional growth |
|  | B) | interstitial growth |
|  | C) | bone remodeling |
|  | D) | endochondral ossification |
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| 20 |  |  Which types of fractures are inherently more likely in children than in adults? |
|  | A) | epiphyseal and greenstick |
|  | B) | transverse and comminuted |
|  | C) | Colles and spiral |
|  | D) | open and closed |
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| 21 |  |  The inadequate mineral deposition in bone caused by a vitamin D deficiency during childhood is called |
|  | A) | scurvy |
|  | B) | rickets |
|  | C) | osteomyelitis |
|  | D) | osteomalacia |
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| 22 |  |  The two hormones that have opposite effects on the rate of osteolysis are |
|  | A) | somatotropin and somatomedin |
|  | B) | growth hormone and thyroid hormone |
|  | C) | parathyroid hormone and calcitonin |
|  | D) | estrogen and testosterone |
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| 23 |  |  Ironically, high levels of ____________ at puberty not only accelerate lengthwise bone growth but also trigger its ultimate end. |
|  | A) | sex hormones |
|  | B) | thyroid gland hormones |
|  | C) | anterior pituitary gland hormones |
|  | D) | parathyroid hormone and somatomedin |
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| 24 |  |  Arrange the following in order of the average age at which they complete ossification, from youngest to oldest: (1) clavicle; (2) lateral epicondyle of humerus; and (3) proximal radius. |
|  | A) | 1, 2, 3 |
|  | B) | 2, 3, 1 |
|  | C) | 3, 1, 2 |
|  | D) | 3, 2, 1 |
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| 25 |  |  Osteopenia and ____________ both reduce bone mass, but the former is a normal part of aging whereas the latter is a disease. |
|  | A) | osteomalacia |
|  | B) | osteomyelitis |
|  | C) | hyperostosis |
|  | D) | osteoporosis |
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