 | Study Outline
(See related pages)
- Regulation VIA Transcription FACTORS
- Structural features of regulatory transcription factors allow them to bind to DNA
- Structural features of regulatory transcription factors allow them to bind to DNA
- Regulatory transcription factors recognize response elements that function as enhancers or silencers
- Regulatory transcription factors may exert their effects through TFIID and mediator
- The function of regulatory transcription factor proteins can be modulated in three ways
- Steroid hormones exert their effects by binding to a regulatory transcription factor and controlling the transcription of nearby genes
- The CREB protein is an example of a regulatory transcription factor modulated by protein-protein interaction and covalent modification
- Changes in Chromatin Structure
- Gene accessibility can be controlled by changes in chromatin structure
- DNaseI sensitivity can be used to study changes in chromatin structure
- Chromatin packing and nucleosome location are altered during globin gene expression
- Transcriptional activators recruit chromatin-remodeling enzymes to the promoter region
- DNA methylation inhibits gene transcription
- DNA methylation is heritable
- Regulation of RNA Processing and Translation
- Alternative splicing regulates which exons occur in an RNA transcript, allowing different proteins to be made from the same structural gene
- The nucleotide sequence of RNA can be modified by RNA editing
- The stability of mRNA influences mRNA concentration
- Double-stranded RNA can mediate mRNA degradation
- Phosphorylation of ribosomal initiation factors can alter the rate of translation
- The regulation of iron assimilation is an example of the regulatory effect of RNA-binding proteins on translation
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