 |
1 | |
The size of the Haemophilus influenzae genome is approximately |
| | A) | 180,000 bases. |
| | B) | 1,800,000 bases. |
| | C) | 18,000,000 bases. |
| | D) | 180,000,000 bases. |
|
|
2 | |
The genome of this organism is generally considered to define the minimum gene set required for life. |
| | A) | Methanococcus janaschii. |
| | B) | Mycoplasma genitalium. |
| | C) | Saccharomyces cerevisiae. |
| | D) | Escherichia coli. |
|
|
3 | |
Which answer lists the genetic maps from the most detailed to the least detailed? |
| | A) | physical sequence cytogenetic linkage |
| | B) | sequence linkage physical cytogenetic |
| | C) | physical sequence linkage cytogenetic |
| | D) | sequence physical linkage cytogenetic |
|
|
4 | |
In the Sanger method of DNA sequencing, DNA synthesis ____ when a dideoxy base is encountered. |
| | A) | commences |
| | B) | continues |
| | C) | stops |
| | D) | increases |
|
|
5 | |
The first organism to have its genome sequenced was |
| | A) | Haemophilus influenzae. |
| | B) | Escherichia coli. |
| | C) | Mycoplasma genitalium. |
| | D) | Saccharomyces cerevisiae. |
|
|
6 | |
Even though the fruit fly Drosophila melanogaster is more complex than the nematode worm Caenorhabditis elegans, the genome of C. elegans revealed that it contained more genes. |
| | A) | true |
| | B) | false |
| | C) | This has not been determined. |
|
|
7 | |
About ____ of the genes in Saccharomyces cerevisiae have counterparts among mammals. |
| | A) | 1/4 |
| | B) | 1/3 |
| | C) | 1/2 |
| | D) | 2/3 |
|
|
8 | |
Chromosomal and linkage maps can be generated using |
| | A) | family data. |
| | B) | RFLP's. |
| | C) | positional cloning. |
| | D) | none of the above. |
|
|
9 | |
The Human Genome Project officially began in _____ under the direction of _____. |
| | A) | 1988, Francis Crick |
| | B) | 1990, James Watson |
| | C) | 1992, J. Craig Venter |
| | D) | 1995, Francis Collins |
|
|
10 | |
Funding for the Human Genome Project comes from |
| | A) | the NIH. |
| | B) | the DOE. |
| | C) | the NIH and the DOE. |
| | D) | the NIH, the DOE and ELSI. |
|
|
11 | |
The Human Genome Project is limited to the study of humans. True or false? |
| | A) | true |
| | B) | false |
|
|
12 | |
In DNA sequencing, the older _____ labels have been replaced by fluorescent labels and polyacrylamide gels have been replaced by _____. |
| | A) | radioactive, agarose gels |
| | B) | radioactive, capillary electrophoresis |
| | C) | expressed sequence tags, capillary electrophoresis |
| | D) | radioactive, computer-generated data |
|
|
13 | |
Genome information will affect your everyday life in many ways. True or false? |
| | A) | true |
| | B) | false |
|
|
14 | |
Of the two groups who worked on the first draft sequence of the human genome |
| | A) | Francis Collins and the International Consortium skipped the BAC stage. |
| | B) | Francis Collins led the effort by Celera Genomics. |
| | C) | Craig Venter's group shotgunned multiple copies of entire genomes into small pieces and used a computer program to assemble the overlaps into larger pieces. |
| | D) | All of the above are true. |
|
|
15 | |
The "Bermuda rules" stated that |
| | A) | researchers had to release new DNA sequences to the public database within 24 hours. |
| | B) | microarray technology could not be used for bioterrorism. |
| | C) | the human genome data would be posted on the internet. |
| | D) | GenBank would be in charge of organizing data regarding the human genome. |
|