Commercial banks provide services that are vital to all sectors of the economy. Failure to efficiently provide these services can be costly to both the suppliers and users of funds. Consequently, CBs are regulated to protect against a breakdown in the provision of CB services. In this chapter, we reviewed the regulations imposed on CBs. We provided an overview of historical and current regulations on CBs' product offerings and geographic expansion opportunities. The recent loosening of regulations in these areas is likely to result in the emergence of many large U.S. CBs as globally oriented universal banks. We also described regulations on the asset and liability portfolios of CBs. The chapter concluded with a look at foreign CB regulations and the regulation of foreign CBs in the United States.