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Rains, Principles of Human Neuropsychology Book Cover
Principles of Human Neuropsychology
G. Dennis Rains, Kutztown University of Pennsylvania

Neural Mechanisms at the Molecular and Cellular Level

Research Links

Historical Significance of the Nervous System

http://psychclassics.yorku.ca/James/Principles/
Web version of William James' Principles of Psychology.

The Neuron

http://www.ultranet.com/~jkimball/BiologyPages/N/Neurons.html
An excellent web page about the neuron. Includes information on the sensory, motor, and interneurons.

http://faculty.purduenc.edu/rhengst/histolog/nerve/n_index.htm
Examples of stained neurons viewed through a microscope.

http://www.physiol.cam.ac.uk/staff/lamb/Papers/TALM95/TALM95.html
An article that compares and contrasts the sensory transduction of vision, hearing, and smell.

http://faculty.washington.edu/chudler/invert.html
An explanation of invertebrate nervous systems with a breakdown by species.

http://www.nobel.se/medicine/articles/golgi/
The Nobel e-Museum's excellent synopsis of Camillo Golgi's life and works; includes photos of brain matter stained with the Golgi stain.

http://www.psu.edu/nasa/cajal.htm
A brief biography of Santiago Ramón y Cajal and a discussion of his accomplishments in the study of the brain.

http://www.nobel.se/medicine/laureates/1906/cajal-bio.html
The Nobel e-Museum's biography of Ramón y Cajal (Nobel Prize winner 1906).

http://www.hhmi.org/senses/b/b110b-1g.htm
Ramón y Cajal's anatomical drawing of the retina cells.

http://www.nobel.se/medicine/laureates/1932/sherrington-bio.html
The Nobel e-Museum's biography of Sir Charles Sherrington (Nobel Prize winner 1932).

The Synapse

http://www.anatomy.usyd.edu.au/online/neuroanatomy/neurons/L8_Synapses.html
An excellent and thorough look at synapses from a University of Sydney Anatomy and Histology course lecture.

http://www.nobel.se/medicine/laureates/1936/loewi-bio.html
The Nobel e-Museum's biography of Otto Loewi (Nobel Prize winner 1936).

http://faculty.washington.edu/chudler/chnt1.html
Great summary of neurotransmitters with a diagram of Loewi's experimental setup.

http://server.bmod.athabascau.ca/html/Psych289/Biotutorials/3/part1.html
This informative tutorial from an Athabasca University psychology course offers several diagrams, terms, references, quizzes, and links related to the synapse.

General Components of the Neuron

http://www.rnceus.com/meth/Introneurotrans.html
A diagram of neuron structures and a description of the neuronal transmission process.

Glia

http://faculty.washington.edu/chudler/glia.html
A basic and informative web page about glia and its functions.

http://biology.about.com/library/weekly/aa020801a.htm Definitions of the different types of glia.

http://members.tripod.com/blustein/index.htm
Definitions of microglia, astrocytes, oligodendrocytes, and Schwann cells.

Molecular and Cellular Level

http://www.tulane.edu/~biochem/faculty/facfigs/bilayer.htm
Detailed images and representations of the lipid bilayer from Tulane University.

http://gwis2.circ.gwu.edu/~atkins/Neuroweb/plasmalemma.html
A tutorial in neuron cell biology from George Washington University.

http://www.mni.mcgill.ca/nm/1999f/en/channels.html
An essay on ion channels.

http://www.fortunecity.com/greenfield/buzzard/387/neuronsascircuit.htm
A description of the neuron as a electrical circuit to explain the flow of ions.

http://biosci211.bsd.uchicago.edu/ligand.pdf
Detailed explanation of the ligand-gated channels from the University of Chicago course, Cellular Neurobiology. Includes diagrams (in an Adobe .pdf file format).

http://jimswan.com/anatomy/neurophysiology_notes.htm
Neurophysiology notes with good diagram links explaining different channels and neurotransmitters.

http://ifcsun1.ifisiol.unam.mx/Brain/action.htm
The cellular mechanisms of the action potential.

http://lshome.utsa.edu/TSI/1999tsi/participants1999/betsy%20landry/beginning.htm
A basic description of the forces acting on the ions within and without the neuron.

http://www.sciam.com/news/012901/1.html
A brief article from Scientific American on glia and their part in building synapses.

Membrane Resting Potential

http://neuro.psyc.memphis.edu/ugp/css006.html
Nice description of all that is necessary to maintain the resting potential of a neuron.

http://www.miracosta.cc.ca.us/home/sfoster/neurons/rest.htm
Text and animated display of the forces involved in the resting potential (including the Na-K pump).

Neuron Activity

http://www.ultranet.com/~jkimball/BiologyPages/E/ExcitableCells.html#threshold
Good synopsis of the neuron's resting and active states.

http://www.science.mcmaster.ca/psychology/psych1a6/1a3/brain/lec2-2.htm
A diagram and brief description of EPSP and IPSP.

http://biosci.usc.edu/documents/bisc307-herrera_011901L.pdf
Neuron activity due to the diversity of synapses. (Adobe .pdf page)

http://soma.npa.uiuc.edu/courses/bio303/Ch8.html
Synaptic integration.

http://www.williams.edu/Neuroscience/courses/Biol304/LEC5.html
Definitive look at length and time constants.

http://www.bbb.caltech.edu/GENESIS/cnsweb/cns2a.html
Spatial and temporal summation with excellent diagrams.

http://web.mit.edu/7.06/www/2001-Lectures/Lecture5-1/sld025.htm
Simple explanation of the generation of an action potential from threshold potentials.

http://gwis2.circ.gwu.edu/~atkins/Neuroweb/Action.html#action
Detailed and pictorial description of the action potential.

http://www.biology.eku.edu/RITCHISO/301notes2.htm
Detailed explanation of the action potential.

http://www.brainviews.com/abFiles/AniSalt.htm
Shockwave animation of saltatory conduction.

http://ist-socrates.berkeley.edu/~jmp/Jo_Calcium_LO.html
Important functions of calcium in the neuron.

Neurotransmitters

http://faculty.washington.edu/chudler/chnt1.html
A very basic, but informative look at neurotransmitters with good, simple diagrams.

http://dog.net.uk/neurotransmitters.html
An excellent list of neurotransmitters (small molecule and neuropeptides).

http://www.wellesley.edu/Chemistry/Chem101/brain/films/films2.html
Quicktime versions of neurotransmitter release.

http://www.shef.ac.uk/~bmsmod/russ.html
Very nice neurotransmitter release descriptions and diagrams.

http://www.utexas.edu/research/asrec/dopamine.html
Description of dopamine as an example of a small molecule neurotransmitter.

http://www.emory.edu/CHEMISTRY/justice/chem190j/feb15.htm
Descriptive site on acetylcholine (another small molecule neurotransmitter).

http://www.hhmi.org/news/brunger.html
Web article on the imaging of neurotransmitter release mechanisms.

http://faculty.washington.edu/chudler/introb.html#drug
Descriptions of legal and illegal drug effects on the brain and neural behavior.

http://microvet.arizona.edu/Courses/MIC420/lecture_notes/clostridia/clostridia_neurotox/movie/botulinum_movie.html
Shockwave animated example of botulin inhibiting acetylcholine release.

http://www.psychiatrist.com/pcc/brainstorm/br6001.htm
Neuropeptide production compared to small molecule neurotransmitters.

http://www.csusm.edu/DandB/AD.html
Antidepressants and their effects.

http://www.sfn.org/briefings/nmda.html
NMDA receptor blockers and their importance in helping with brain disorders.

http://salmon.psy.plym.ac.uk/year1/schizophrenia.htm
An in-depth site on schizophrenia and all its aspects.

http://gwis2.circ.gwu.edu/~atkins/Neuroweb/synapse.html#second
Second messengers.

Learning at the Neural Level

http://www.williams.edu/Neuroscience/course/Biol304/LEC5.html
A detailed site on cellular learning in the sea slug (Aplysia).

http://www.nobel.se/medicine/laureates/2000/
Information on Erik Kandel, who received the 2000 Nobel prize in physiology or medicine for his groundbreaking work on learning at the cellular level using the nervous system of a sea slug (Aplysia) as an experimental model.

Electrical Synapses (Gap Junctions)

http://desmid.biol.mun.ca/brian/BIOL2060/CellBiol9b/CB9_20.html
Definition and diagram of an electrical synapse.

http://www.science.wayne.edu/~bio340/Synapses/img005.htm
A good diagram of a gap junction.