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1 | | The average length of a gene in the unique sequences of the Drosophila genomic DNA is 8-9 kb. |
| | A) | True |
| | B) | False |
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2 | | Fertilization takes place in Drosophila before the oocyte completes meiosis. |
| | A) | True |
| | B) | False |
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3 | | In Drosophila, body segments first appear in the adult. |
| | A) | True |
| | B) | False |
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4 | | In Drosophila, nerve cells arise from the ventral ectoderm. |
| | A) | True |
| | B) | False |
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5 | | Drosophila compensates for the loss of telomeric DNA by adding repeats. |
| | A) | True |
| | B) | False |
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6 | | Cell fate which is determined at least in part by neighboring cells exemplifies: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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7 | | A chromosome which does not undergo recombination by virtue of its physical map exemplifies: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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8 | | A nucleotide sequence which appears within the coding sequence of genes and regulates segment-specific tissues is: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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9 | | A protein sequence which confers binding to segment-specific regulatory sequences within genes is: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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10 | | A substance that defines different cell fates in a concentration-dependent manner is a: |
| | A) | morphogen |
| | B) | homeodomain |
| | C) | balancer |
| | D) | homeobox |
| | E) | nonautonomous trait |
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11 | | P-element transposition is responsible for: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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12 | | Mutations in the bithorax complex (BX-C) can result in: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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13 | | Invagination of a band of midventral cells in the embryo is the first step of: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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14 | | Control of developmental genes can be linked to reporter enzyme(s) by: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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15 | | The transition from larva to adult occurs by: |
| | A) | ectopic expression |
| | B) | enhancer trapping |
| | C) | hybrid dysgenesis |
| | D) | gastrulation |
| | E) | metamorphosis |
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16 | | The Pax6 gene in mice is homologous to the Drosophila gene: |
| | A) | sevenless |
| | B) | vestigial |
| | C) | ultrabithorax |
| | D) | eyeless |
| | E) | bride of sevenless |
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17 | | Which of the following is not true of Drosophila development? |
| | A) | head arises from three segments |
| | B) | thorax arises from three segments |
| | C) | abdomen arises from eight segments |
| | D) | bicoid is a posterior mRNA |
| | E) | Nanos is a posterior protein |
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18 | | Order the following classes of genes according to their hierarchy of function in early embryogenesis: A. pair rule genes, B. homeotic genes, C. gap genes, D. segment polarity genes, E. maternal genes |
| | A) | CDABE |
| | B) | ECDAB |
| | C) | BCADE |
| | D) | ACBED |
| | E) | DEABC |
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19 | | Hybrid dysgenesis occurs in: |
| | A) | male P strains mated with female M strains |
| | B) | male M strains mated with female P strains |
| | C) | male M strains mated with female M strains |
| | D) | male P strains mated with female P strains |
| | E) | a & b |
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20 | | Order the following stages in Drosophila embryogenesis: A. cellular blastoderm, B. syncitial blastoderm, C. gastrulation, D. fertilization, E. segmentation |
| | A) | DCBAE |
| | B) | ADCEB |
| | C) | DBACE |
| | D) | CDABE |
| | E) | DABCE |
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21 | | Imaginal discs give rise to body segments in Drosophila development? |
| | A) | True |
| | B) | False |
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22 | | In general, the developmental potential of cells becomes more and more restricted as development proceeds |
| | A) | True |
| | B) | False |
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23 | | The bride of sevenless (boss) gene is cell autonomous. |
| | A) | True |
| | B) | False |
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24 | | Pole cells are the first cells formed during embryonic development in Drosophila. |
| | A) | True |
| | B) | False |
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25 | | The distribution of hunchback mRNA in the oocyte immediately prior to fertilization is a gradient from anterior (highest) to posterior (lowest). |
| | A) | True |
| | B) | False |
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26 | | Transposase is encoded by: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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27 | | Nuclei can respond directly to morphogen gradients in: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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28 | | A clone of cells limited to a specific region but not necessarily a particular fate is: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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29 | | Small groups of cells set aside in the embryo for future organogenesis are: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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30 | | Signal transduction must take over for transmission of regulatory gradients after development of the embryonic: |
| | A) | P elements |
| | B) | lineage compartment |
| | C) | imaginal discs |
| | D) | syncitial blastoderm |
| | E) | cellular blastoderm |
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31 | | Genes that determine certain patterns that are repeated in each segment are: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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32 | | Genes which divide the body axis into rough, generalized regions are: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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33 | | Genes that subdivide the developing embryo into two-segment units are: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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34 | | The Antennapedia complex is an example of: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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35 | | The distribution of bicoid is determined by: |
| | A) | homeotic genes |
| | B) | maternal genes |
| | C) | pair-rule genes |
| | D) | segment polarity genes |
| | E) | gap genes |
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36 | | To function as a balancer, a chromosome should: |
| | A) | have large rearrangements |
| | B) | be holocentric |
| | C) | have many repetitive sequences |
| | D) | a & b |
| | E) | b & c |
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37 | | A cross of two individuals of a 'balanced lethal' strain yields: |
| | A) | 50% viable progeny homozygous for both markers |
| | B) | 25% viable progeny heterozygous for both markers |
| | C) | 50% viable progeny heterozygous for both markers |
| | D) | 25% viable progeny homozygous for both markers |
| | E) | none of the above |
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38 | | What is the function of the lacZ structural gene associated with the P-element promoter in an enhancer trap? |
| | A) | confer Lac+ on transformants |
| | B) | select bacteria in plasmid rescue |
| | C) | report on neighboring regulatory sequences |
| | D) | all of the above |
| | E) | none of the above |
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39 | | The 'Sander' model for body axis patterning described in this chapter has which of the following elements? |
| | A) | spatial gradients of mRNA |
| | B) | spatial gradients of proteins |
| | C) | spatial gradients of gene expression |
| | D) | a & b |
| | E) | all of the above |
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40 | | Order the following genes according to their hierarchy of function in early embryogenesis: A. fushi tarazu, B. hedgehog, C. bicoid, D. hunchback, E. antennapedia |
| | A) | BCAED |
| | B) | ADEBC |
| | C) | DBAEC |
| | D) | EACBD |
| | E) | CDABE |
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